Beyond focal cortical lesions in MS

Cortical Lesions in MS: Assessment at 7T

Introduction Multiple sclerosis is generally thought of as a white matter (WM) disease [1], yet there is limited correlation between white matter lesion (WML) load and neurological deficits found clinically [2]. Cortical damage was identified early [3,4] and has recently been correlated with the neurological episodes of MS patients [5]. Pathologically, cortical lesions (CLs) are classified into...

Focal lesions in cirrhotic liver: what else beyond hepatocellular carcinoma?

Detection and characterization of focal lesions in the cirrhotic liver may pose a diagnostic dilemma. Several benign and malignant lesions may be found in a cirrhotic liver along with hepatocellular carcinoma (HCC), and may exhibit typical or atypical imaging features. In this pictorial essay, we illustrate computed tomography and magnetic resonance imaging findings of lesions such as simple bi...

Focal cortical dysplasia-associated tumors: resecting beyond the lesion.

Commentary Low-grade supratentorial tumors constitute 10 to 40% of the pathological diagnoses in patients following resective surgery for refractory focal-onset epilepsy (1, 2). The most common tumor subtypes in this group include inherently indolent and intrinsically epileptogenic gangliogliomas (GG) (3) and dys-embryoplastic neuroepithelial tumors (DNT). Temporal lobe tumors in this group exh...

A computational model of acute focal cortical lesions.

BACKGROUND AND PURPOSE Determining how cerebral cortex adapts to sudden focal damage is important for gaining a better understanding of stroke. In this study we used a computational model to examine the hypothesis that cortical map reorganization after a simulated infarct is critically dependent on perilesion excitability and to identify factors that influence the extent of poststroke reorganiz...

Do cortical lesions help us to distinguish MS from NMO?